United States securities and exchange commission logo

                          November 10, 2021

       Theodore (Ted) Ashburn
       Chief Executive Officer
       Oncorus, Inc.
       50 Hampshire Street, Suite 401
       Cambridge, Massachusetts 02139

                                                        Re: Oncorus, Inc.
Statement on Form S-3
                                                            Filed November 3,
                                                            File No. 333-260718

       Dear Dr. Ashburn:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Jordan
Nimitz at 202-551-5831 with any questions.


                          Division of Corporation Finance

                          Office of Life Sciences